abstract：:The role of endogenous opioid peptides in the control of gonadotropin-releasing hormone pulse generator activity was examined in long-term ovariectomized goats by recording the hypothalamic multiple-unit activity specifically associated with pulsatile luteinizing hormone secretion (MUA volleys). Administration of nalo...

journal_title：Neuroendocrinology

authors： Ito K,Tanaka T,Mori Y

更新日期：1993-04-01 00:00:00

abstract：:Prolactin release from primary cultured pituitary cells was investigated using a dynamic perifusion system. Although epinephrine (1 mumol/l) produced an elevation in the mean value of the prolactin concentration at the onset of the perifusion, the elevation was not statistically significant, and the overall effect of ...

journal_title：Neuroendocrinology

authors： Shin SH,Barton RE

更新日期：1993-04-01 00:00:00

abstract：:The known occurrence of opiates in the adrenals stimulated us to determine whether Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2), an endogenous peptide that can act as an antiopiate, is present in these glands and whether adrenalectomy affects its concentrations in plasma. The presence of Tyr-MIF-1 in the adrenals of the rat was sh...

journal_title：Neuroendocrinology

authors： Kastin AJ,Fabre L,Banks WA,Zadina JE

更新日期：1993-03-01 00:00:00

abstract：:Activin A immunoreactivity has been localized within the nucleus tractus solitarius and its projections into regions of the hypothalamus such as the paraventricular nucleus. However, the function of activin within the central nervous system is unclear. Because these regions of the brain are involved in the regulation ...

journal_title：Neuroendocrinology

authors： Schwall RH,Jakeman LB,Altar CA

更新日期：1993-03-01 00:00:00

abstract：:The c-fos protein is rapidly induced in hypothalamic magnocellular nuclei following hemorrhage. We used specific antibodies directed against c-fos and either vasopressin (AVP) or oxytocin (OT) neurophysin to investigate c-fos activation in individual AVP and OT neurons. AVP and OT neurons expressed c-fos in response t...

journal_title：Neuroendocrinology

authors： Roberts MM,Robinson AG,Fitzsimmons MD,Grant F,Lee WS,Hoffman GE

更新日期：1993-03-01 00:00:00

abstract：:Chronic hyperprolactinemia in the rat is associated with suppression of plasma gonadotropin concentrations. The reduction of gonadotropins is considered to be due to either an inhibitory effect of prolactin (PRL) on pituitary gonadotropin secretion and/or suppression of hypothalamic gonadotropin-releasing hormone (GnR...

journal_title：Neuroendocrinology

authors： Calogero AE,Weber RF,D'Agata R

更新日期：1993-01-01 00:00:00

abstract：:We have previously reported that the somatotropin regulatory peptides, growth hormone-releasing hormone (GRF) and somatostatin (SS) increase feeding when applied centrally in low picomole-range doses. The similarity between the dose-response characteristics and photoperiod sensitivities of these two peptide's feeding ...

journal_title：Neuroendocrinology

authors： Feifel D,Vaccarino FJ,Rivier J,Vale WW

更新日期：1993-01-01 00:00:00

abstract：:We studied the effect that beta-endorphin (beta END) might have at the median eminence (ME) on luteinizing hormone (LH)-releasing hormone (LHRH) during the ovulatory cycle of domestic hens. Thus, we assessed (a) the immunocytochemical distribution of beta END and LHRH in the hen ME, (b) the temporal changes in ME and ...

journal_title：Neuroendocrinology

authors： Contijoch AM,Malamed S,Sarkar DK,Advis JP

更新日期：1993-01-01 00:00:00

abstract：:His-dTrp-Ala-Trp-dPhe,Lys-NH2(GHRP-6) is a synthetic compound that releases GH in a dose-response and specific manner in several species and that may well be related to an endogenous compound of similar structure. The aim of this study was to investigate the in vivo GH responses to GHRP-6 in pentobarbital anesthetized...

journal_title：Neuroendocrinology

authors： Mallo F,Alvarez CV,Benitez L,Burguera B,Coya R,Casanueva FF,Dieguez C

更新日期：1993-01-01 00:00:00

abstract：:The concentrations in plasma of the biologically active endogenous peptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) have not been measured during development or in female rats. By radioimmunoassay, we found that Tyr-MIF-1-like immunoreactivity (Tyr-MIF-1-LI) was first consistently detectable in plasma when the rat was 5 days o...

journal_title：Neuroendocrinology

authors： Kastin AJ,Fabre L,Brown MM,Olson RD

更新日期：1992-12-01 00:00:00

abstract：:The sheep exhibits a marked sex difference in the timing of the pubertal increase in luteinizing hormone (LH). Male lambs undergo a reduction in sensitivity to inhibitory steroid feedback, leading to an increase in LH by 10 weeks of age, but females remain hypersensitive until 30 weeks of age. Endogenous opioids suppr...

journal_title：Neuroendocrinology

authors： Wood RI,I'Anson H,Ebling FJ,Foster DL

更新日期：1992-12-01 00:00:00

abstract：:Observations of long standing have suggested that the 'stress' of chair restraint inhibits the GnRH pulse generator in normal female monkeys while this phenomenon is rarely observed in ovariectomized animals. The role of the ovary in the response of the GnRH pulse generator to the stress of insulin hypoglycemia was in...

journal_title：Neuroendocrinology

authors： Chen MD,O'Byrne KT,Chiappini SE,Hotchkiss J,Knobil E

更新日期：1992-11-01 00:00:00

abstract：:Interruption of hypothalamic growth hormone-releasing hormone (GHRH) secretion by administration of antiserum against GHRH (GHRH-ab) decreases growth hormone (GH) secretion and inhibits growth in rats. The present study was undertaken to investigate whether there is a period of accelerated or catch-up growth following...

journal_title：Neuroendocrinology

authors： Wehrenberg WB,Voltz DM,Cella SG,Müller EE,Gaillard RC

更新日期：1992-10-01 00:00:00

abstract：:Insulin-deficient states are associated with an impaired function of the hypothalamic-pituitary-gonadal axis, but the mechanisms underlying hypothalamic alterations in experimental diabetes are still unknown. We investigated the effect of glucose concentrations, in the presence and absence of insulin, on LHRH release ...

journal_title：Neuroendocrinology

authors： Arias P,Rodríguez M,Szwarcfarb B,Sinay IR,Moguilevsky JA

更新日期：1992-09-01 00:00:00

abstract：:Previous studies indicate that 7 days after testicular administration of naloxone, serum testosterone (T) concentration and basal T secretion in vitro decrease significantly. In neonatal rats, short-term (2 h) intratesticular treatment with 0.3 micrograms (D-Met2-Pro5)-enkephalinamide suppresses steroidogenesis. In th...

journal_title：Neuroendocrinology

authors： Gerendai I,Nemeskéri A,Csernus V

更新日期：1992-09-01 00:00:00

abstract：:Histamine (HA) stimulates the release of the pro-opiomelanocortin (POMC)-derived peptides ACTH, beta-endorphin (beta-END), beta-lipotropin and alpha-melanocyte-stimulating hormone, and HA is involved in the mediation of the stress-induced release of these peptides. The effect of HA is indirect and may involve the hypo...

journal_title：Neuroendocrinology

authors： Kjaer A,Knigge U,Bach FW,Warberg J

更新日期：1992-09-01 00:00:00

abstract：:Somatostatin receptors on lactotroph cells of the anterior pituitary are positively regulated by estradiol. In the present work, we investigated whether estradiol regulation of somatostatin receptors also occurred in the female rat brain. 125I-Tyr0-DTrp8-somatostatin (125I-SRIF: 780 Ci/mM) was used as a ligand. Female...

journal_title：Neuroendocrinology

authors： Slama A,Videau C,Kordon C,Epelbaum J

更新日期：1992-08-01 00:00:00

abstract：:Pituitary oxytocin (OT) secretion is inversely related to saline consumption in several experimental models of sodium appetite in rats. Because systemic OT administration does not inhibit sodium appetite, release of OT as a neurotransmitter within the brain, coincident with its secretion from the pituitary, may be rel...

journal_title：Neuroendocrinology

authors： Blackburn RE,Stricker EM,Verbalis JG

更新日期：1992-08-01 00:00:00

abstract：:Brain angiotensin II (AII) receptors play a role in the regulation of luteinizing hormone release. This action is thought to involve luteinizing hormone-releasing hormone containing neurons in the preoptic-anterior hypothalamic (POAH) area of the brain. Previous studies have demonstrated a discrete locus of AII recept...

journal_title：Neuroendocrinology

authors： Grove KL,Cook VI,Speth RC

更新日期：1992-08-01 00:00:00

abstract：:The effects of intracerebroventricularly (i.c.v.) injected interleukin-1 beta (IL-1 beta: 1, 2.5, 10, and 25 ng) were studied on plasma growth hormone (GH) and prolactin (PRL) concentrations in freely moving rats chronically implanted with i.c.v. cannulas and intracardial catheters. Significant changes in PRL secretio...

journal_title：Neuroendocrinology

authors： Payne LC,Obal F Jr,Opp MR,Krueger JM

更新日期：1992-07-01 00:00:00

abstract：:The purpose of the present study was to examine whether repetitive intravenous injections of L-glutamic acid (Glu), like those of N-methyl-D,L-aspartic acid (NMA), are able to elicit a sustained train of gonadotropin releasing hormone (GnRH) discharges from the hypothalamus of the prepubertal male monkey. In order to ...

journal_title：Neuroendocrinology

authors： Medhamurthy R,Gay VL,Plant TM

更新日期：1992-06-01 00:00:00

abstract：:We have previously shown that the serotonergic regulation of renin secretion from the kidneys is mediated by a renin-releasing factor (RRF) that is present in both plasma and hypothalamus. The present studies were designed to determine the distribution of RRF in the brain and peripheral tissues and to test whether RRF...

journal_title：Neuroendocrinology

authors： Urban JH,Brownfield MS,Levine JE,Van de Kar LD

更新日期：1992-05-01 00:00:00

abstract：:The effects of adrenalectomy (ADX) and dexamethasone (DEX) treatment on brain dopamine (DA) receptors of ovariectomized (OVX) rats were investigated by autoradiography using binding of the D1 and D2 antagonists ligands [3H]SCH 23390 and [3H]spiperone, respectively. Fourteen days after ADX, D1 receptors decreased in th...

journal_title：Neuroendocrinology

authors： Biron D,Dauphin C,Di Paolo T

更新日期：1992-04-01 00:00:00

abstract：:Male Turkish hamsters received horizontal knife cuts within the hypothalamus to investigate the role of afferent and efferent projections of the paraventricular nucleus (PVN) in seasonal regulation of endocrine function. Following surgery, the animals were exposed to either a long (16 h light/8 h dark) or a short (8 h...

journal_title：Neuroendocrinology

authors： Badura LL,Goldman BD

更新日期：1992-04-01 00:00:00

abstract：:The facilitation of sexual receptivity by oxytocin (OT) in female rats is related to the regulation of oxytocin receptors (OTR) by ovarian steroids in the ventromedial nuclei (VMN) of the hypothalamus. In a previous study, we have shown that estradiol benzoate (EB) causes a twofold increase in OTR binding in the VMN. ...

journal_title：Neuroendocrinology

authors： Coirini H,Johnson AE,Schumacher M,McEwen BS

更新日期：1992-03-01 00:00:00

abstract：:To gain further insight into the regulation of hypothalamic TRH by thyroid hormones, we measured TRH concentration in specific hypothalamic nuclei and preproTRH mRNA levels in the anterior hypothalamus. Adult male rats were decapitated 1, 7, 14 days after thyroidectomy. Micropunches by the method of Palkovitz from sev...

journal_title：Neuroendocrinology

authors： Yamada M,Satoh T,Monden T,Murakami M,Iriuchijima T,Wilber JF,Mori M

更新日期：1992-03-01 00:00:00

abstract：:The caudal portion of the spinal cord of elasmobranch fish incorporates a diffuse neuroendocrine system. Using an antiserum raised against urotensin II from a teleost fish (goby) to facilitate purification, a peptide structurally related to urotensin II was isolated in pure form from an extract of neuroendocrine tissu...

journal_title：Neuroendocrinology

authors： Conlon JM,O'Harte F,Smith DD,Balment RJ,Hazon N

更新日期：1992-02-01 00:00:00

abstract：:To determine the possible physiological role of endogenous growth hormone-releasing factor (GRF) in the neuronal content and release of cerebral somatostatin (SS), we studied the effect of endogenous GRF blockade on the immunoreactive SS (IR-SS) content of cells and media in fetal rat cerebral cortical and hypothalami...

journal_title：Neuroendocrinology

authors： de los Frailes MT,Cacicedo L,Fernandez G,Tolón RM,Jesus Lorenzo M,Aguado F,Sánchez Franco F

更新日期：1992-02-01 00:00:00

abstract：:Delta-sleep-inducing peptide (DSIP) colocalizes within gonadotropin-releasing-hormone (GnRH)-containing neurons in adult hypothalamus and could play a role in the regulation of hypothalamic-pituitary axis in adults. To support the possibility that DSIP also participates in fetal neuroendocrine events and to demonstrat...

journal_title：Neuroendocrinology

authors： Pu LP,Dubois PM

更新日期：1992-01-01 00:00:00

abstract：:We used an in vivo pharmacological approach to investigate the potential influence of serotonin (5-HT) on peptide release from the intermediate lobe (IL) of the rat pituitary. Plasma levels of alpha-melanocyte-stimulating hormone (alpha-MSH) as well as the ultrastructural appearance of IL cells were used as indicators...

journal_title：Neuroendocrinology

authors： Carr JA,Saland LC,Samora A,Benavidez S,Krobert K

更新日期：1991-12-01 00:00:00

abstract：:We have investigated the variations in growth hormone (GH) and somatostatin (SOM) mRNAs in adult, middle-aged and aging rats of both sexes using quantitative in situ hybridization. cDNA probes complementary to GH mRNA and SOM mRNA were used on fixed pituitary and hypothalamic sections, respectively. A clear sexual dim...

journal_title：Neuroendocrinology

authors： Martinoli MG,Ouellet J,Rhéaume E,Pelletier G

更新日期：1991-12-01 00:00:00

abstract：:The aim of this study was to verify whether prolonged exposure of cultured rat anterior pituitary cells to high glucose can alter growth hormone (GH) release and responsiveness to secretagogues. Therefore, we cultured anterior pituitary cells obtained from normal male Sprague-Dawley rats in presence of normal (6 mM) o...

journal_title：Neuroendocrinology

authors： Renier G,Serri O

更新日期：1991-11-01 00:00:00

abstract：:Quantitative autoradiography was used to evaluate the effects of sex and either 1 or 5 daily 2-hour sessions of restraint stress on binding at 5-HT1A, 5-HT1C and 5-HT2 receptors in the rat dorsal hippocampus. Neither sex nor restraint stress were found to have effects on binding at 5-HT1C or 5-HT2 receptors. However, ...

journal_title：Neuroendocrinology

authors： Mendelson SD,McEwen BS

更新日期：1991-11-01 00:00:00

abstract：:We have previously shown that the diterpene forskolin, a compound which increases intracellular cyclic AMP (cAMP), causes a concentration-dependent release of luteinizing hormone (LH) by continuously perifused anterior pituitary cells from female rats. To test the hypothesis that cAMP-associated LH release is an estro...

journal_title：Neuroendocrinology

authors： Kolp LA,Krieg RJ Jr,Evans WS

更新日期：1991-10-01 00:00:00

abstract：:The push-pull perfusion technique, in conjunction with specific radioimmunoassays, was used to monitor the release of both arginine vasopressin (AVP) and oxytocin (OXT) within distinct limbic brain areas of conscious female rats. In pregnant rats near term, the release of AVP was greater than that of virgin rats in bo...

journal_title：Neuroendocrinology

authors： Landgraf R,Neumann I,Pittman QJ

更新日期：1991-10-01 00:00:00

abstract：:In the present study we utilized the 7315a PRL- and ACTH-secreting tumor to induce a hyperprolactinemic (HP) state sufficient to profoundly suppress the postcastration LH rise in female rats. Tumor-induced prolactin levels which ranged 2,000-3,000 ng/ml substantially reduced the LH rise in both ovariectomized (OVX) an...

journal_title：Neuroendocrinology

authors： Shu C,Selmanoff M

更新日期：1991-09-01 00:00:00

abstract：:The electrical properties of GH3 cells, a transformed line from the rat pituitary, were studied with a current-clamp technique in the presence of triiodothyronine (T3) and reverse triiodothyronine (rT3) and compared with the known effects of T3. rT3 had an effect only in a concentration of 1 microM; action potentials ...

journal_title：Neuroendocrinology

authors： du Pont JS

更新日期：1991-08-01 00:00:00

abstract：:The present study was designed to investigate whether the vasoactive intestinal peptide (VIP) concentration in hypothalamic nuclei, dorsal raphe nucleus (DR) and pituitary lobes of lactating rats changes in physiological situations when prolactin (PRL) secretion is stimulated (suckling) or inhibited (pup separation). ...

journal_title：Neuroendocrinology

authors： Chiocchio SR,de las Nieves Parisi M,Vitale ML,Tramezzani JH

更新日期：1991-07-01 00:00:00

abstract：:A number of neurochemical messengers have been shown to act directly on the melanotrope cells of the pars intermedia of Xenopus laevis to regulate alpha MSH secretion. In the present study the possibility that the melanotropes are also indirectly controlled has been examined. For this purpose, the characteristics of a...

journal_title：Neuroendocrinology

authors： de Koning HP,Jenks BG,Scheenen WJ,de Rijk EP,Caris RT,Roubos EW

更新日期：1991-07-01 00:00:00

abstract：:In vivo and in vitro methods have been used to compare the effects of opioid receptor blockade on the functional activity of the hypothalamo-pituitary-gonadal axis in adult (200 g) and sexually immature (50 g) male rats. In the adult, a single injection of the mu-receptor antagonist, naloxone (500 micrograms/100 g bod...

journal_title：Neuroendocrinology

authors： Leposavic G,Cover PO,Buckingham JC

更新日期：1991-06-01 00:00:00